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Article: Platelet-Rich Plasma (PRP): Current Applications in Dermatology

Emer, Jason

2019 Volume 24, Issue 5, Page(s) 1–6

Abstract: Platelet-rich plasma (PRP) is an autologous serum containing high concentrations of platelets and growth factors. PRP continues to evolve as an important treatment modality with many applications in dermatology, particularly in the areas of hair ... ...

Abstract	Platelet-rich plasma (PRP) is an autologous serum containing high concentrations of platelets and growth factors. PRP continues to evolve as an important treatment modality with many applications in dermatology, particularly in the areas of hair restoration, skin rejuvenation, acne scars, dermal augmentation, and striae distensae. Furthermore, combining PRP with laser therapies, microneedling, dermal fillers, and autologous fat grafting produces synergistic effects, leading to improved aesthetic results. Future studies should standardize PRP treatment protocols for specific indications. PRP holds considerable promise in dermatology with therapeutic applications continuing to expand.
MeSH term(s)	Alopecia/therapy ; Cicatrix/therapy ; Cosmetic Techniques ; Dermatology ; Humans ; Platelet-Rich Plasma ; Rejuvenation ; Striae Distensae/therapy
Language	English
Publishing date	2019-10-04
Publishing country	Canada
Document type	Journal Article ; Review
ZDB-ID	2065394-3
ISSN	1201-5989
ISSN	1201-5989
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Best practices and evidenced-based use of the 800 nm diode laser for the treatment of pseudofolliculitis barbae in skin of color.

Emer, Jason J

Journal of drugs in dermatology : JDD

2011 Volume 10, Issue 12 Suppl, Page(s) s20–2

MeSH term(s)	Folliculitis/therapy ; Hair Removal/methods ; Humans ; Lasers, Semiconductor/adverse effects ; Lasers, Semiconductor/therapeutic use ; Male ; Skin Pigmentation
Language	English
Publishing date	2011-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	2145090-0
ISSN	1545-9616
ISSN	1545-9616
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Zs.A 5931: Show issues

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Article: Combination Therapy for Acne Scarring: Personal Experience and Clinical Suggestions.

Kroepfl, Lucija / Emer, Jason J

Journal of drugs in dermatology : JDD

2016 Volume 15, Issue 11, Page(s) 1413–1419

Abstract: ... those on concurrent isotretinoin. J Drugs Dermatol. 2016;15(11):1413-1419.. ...

Abstract	Acne is one of the most prevalent skin conditions seen by dermatologists. The cosmetic sequelae of severe acne, including scarring and pigmentation, have a profound psychological impact on those in icted. Topical (eg, retinoids, antibiotics, dapsone, hydroxyacids) and oral treatments (eg, antibiotics and/or spironolactone) are often bene cial to control acne or in the instance of oral isotretinoin use, rid the acne permanently; however, these treatments have very little affect on the ultimate cosmetic outcome of the acne scarring and skin texture that results. Given the variety of scar types that can form and the variability of responses seen in various skin types and textures, treatment options are vast without appropriate guidelines for pathways that dictate best timing, combinations, and options in given clinical scenarios. Current treatment options include solo or combina- tions of energy-based (eg, laser, radiofrequency), chemical-based (eg, peels, TCA cross), surgical-based options (eg, subcision, punch excision), microneedling, and llers and/or fat injections. Most recently, fractional radiofrequency-based treatments have been used to improve acne scarring with less reported downtime as compared to lasers or chemical peels and the ability to treat darker or sensitive skin types with less risk of scarring or hyperpigmentation. In severe cystic ares, scarring treatments are often postposed till the acne is under control and in many instances this can limit the dermatologists ability to affect future cosmetic treatments. Based on personal experience of various clinical scenarios in a busy laser practice that treats a signi cant number of patients with acne scarring, fractional radiofrequency is an excellent choice for treating all forms of acne scars with minimal risk to patients, even those on concurrent treatments such as isotretinoin. Additionally, fractional radiofrequency can be used in combination with all other treatment options to speed the time to clinical improvement appreciated by the patient. Here we present personal experiences of combination treatments for acne scarring, pigmentation and textural issues, and suggest that fractional radiofrequency be considered a "gold standard" treatment of acne scarring in those with dark or sensitive skin types or those on concurrent isotretinoin. <em>J Drugs Dermatol. 2016;15(11):1413-1419.</em>.
MeSH term(s)	Acne Vulgaris/diagnosis ; Acne Vulgaris/therapy ; Chemexfoliation ; Cicatrix/diagnosis ; Cicatrix/therapy ; Combined Modality Therapy/methods ; Female ; Humans ; Lasers, Gas/therapeutic use ; Low-Level Light Therapy/methods ; Male ; Radio Waves/therapeutic use ; Young Adult
Language	English
Publishing date	2016-11-01
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	2145090-0
ISSN	1545-9616
ISSN	1545-9616
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Article ; Online: Is There a Potential Role for Anti-tumor Necrosis Factor Therapy in Patients with Human Immunodeficiency Virus?

Emer, Jason J

The Journal of clinical and aesthetic dermatology

2010 Volume 2, Issue 4, Page(s) 29–35

Abstract: Anti-tumor necrosis factor therapy has shown remarkable safety and efficacy in the treatment of many autoimmune and inflammatory disorders, although limited published data exists regarding these treatments in patients with concomitant human ... ...

Abstract	Anti-tumor necrosis factor therapy has shown remarkable safety and efficacy in the treatment of many autoimmune and inflammatory disorders, although limited published data exists regarding these treatments in patients with concomitant human immunodeficiency virus and/or acquired immune deficiency syndrome. The use of tumor necrosis factor inhibition is associated with an increased risk of severe infections, including tuberculosis and risk of worsening hepatitis B virus, but its effect on viral infections is conflicting. Currently, package inserts for the three anti-tumor necrosis factor medications (infliximab, etanercept, and adalimumab) affirm that caution should be exercised when considering their use in patients with chronic infection or a history of recurrent infection, as clinical trials for these medications have historically excluded patients with chronic viral infections. With the increasing prevalence of chronic viral infections in patients who are candidates for anti-tumor necrosis factor therapy, there is reason for additional research to assess the safety, efficacy, and potential role of tumor necrosis factor inhibition in this population. This article is an up-to-date review of the emerging use of biologic therapies in patients infected with the human immunodeficiency virus and concurrent psoriatic or rheumatological disease.
Language	English
Publishing date	2010-08-23
Publishing country	United States
Document type	Journal Article
ISSN	2689-9175
ISSN (online)	2689-9175
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Did physical activity and associated barriers change during COVID-19 restrictions in Ireland? Repeated cross-sectional study.

Barrett, Emer M / Wyse, Jason / Forde, Cuisle

Health promotion international

2022 Volume 37, Issue 4

Abstract: This repeated cross-sectional study investigated physical activity and associated barriers and facilitators during the first two waves of COVID-19 restrictions in Ireland. An online, anonymous questionnaire collated data from adults during May (n = 1274) ...

Abstract	This repeated cross-sectional study investigated physical activity and associated barriers and facilitators during the first two waves of COVID-19 restrictions in Ireland. An online, anonymous questionnaire collated data from adults during May (n = 1274) and November (n = 810) 2020. Statistical analysis used a combination of traditional significance testing and Bayesian lasso logistic regression. The pattern of physical activity changed significantly between waves (χ2 86.8 on 3df; p < 0.001). During wave 1 restrictions, the majority [46.1% (n = 587)] of participants reported being more active than usual, decreasing to 26.3% (n = 213) during wave 2. More participants reported that their activity levels were less than usual [W1 29% (n = 369); W2 35% (n = 283)] during wave 2. Adherence to physical activity guidelines decreased from 56.5% (n = 705) to 43.7% (n = 35). Being unable to access their usual means of exercise [OR, 95% OR intervals; W1 1.611 (1.370-1.904), W2 1.638 (1.3731.968)] and advice not to leave home [OR, 95% OR intervals; W1 1.401 (1.164-1.697), W2 1.367 (1.106-1.696)] predicted less activity than usual during both waves. Increased time [OR, 95% OR intervals; W1 2.326 (1.948-2.794), W2 1.809 (1.478-2.233)], and valuing physical activity as important [OR, 95% OR intervals; W1 1.192 (1.001-1.444), W2 1.253 (1.003-1.637)] predicted increased activity during both waves, whilst finding new ways to be active [OR, 95% OR intervals; 2.515 (1.641-3.887)] predicted more activity in wave 2 only. Increases in physical activity of Irish adults during the first phase of COVID-19 restrictions were not maintained during the second wave and barriers to physical activity persisted.
MeSH term(s)	Adult ; Bayes Theorem ; COVID-19/prevention & control ; Cross-Sectional Studies ; Exercise ; Humans ; Ireland/epidemiology
Language	English
Publishing date	2022-08-05
Publishing country	England
Document type	Journal Article
ZDB-ID	1027448-0
ISSN	1460-2245 ; 0957-4824
ISSN (online)	1460-2245
ISSN	0957-4824
DOI	10.1093/heapro/daac127
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Article ; Online: Association of Incident Stroke Risk With an IL-18-Centered Inflammatory Network Biomarker Composite.

Martirosian, Richard A / Wiedner, Crystal D / Sanchez, Jasmin / Mun, Katherine T / Marla, Kiran / Teran, Cristina / Thirion, Marissa / Liebeskind, David S / McGrath, Emer R / Zucker, Jared M / Bernal, Rebecca / Beiser, Alexa S / DeCarli, Charles / Himali, Jayandra J / Seshadri, Sudha / Hinman, Jason D

Stroke

2024

Abstract: Background: A coordinated network of circulating inflammatory molecules centered on the pleotropic pro-atherogenic cytokine interleukin-18 (IL-18) is linked to cerebral small vessel disease. We sought to validate the association of this inflammatory ... ...

Abstract	Background: A coordinated network of circulating inflammatory molecules centered on the pleotropic pro-atherogenic cytokine interleukin-18 (IL-18) is linked to cerebral small vessel disease. We sought to validate the association of this inflammatory biomarker network with incident stroke risk, cognitive impairment, and imaging metrics in a sample of the Framingham Offspring Cohort. Methods: Using available baseline measurements of serum levels of IL-18, GDF (growth and differentiation factor)-15, soluble form of receptor for advanced glycation end products, myeloperoxidase, and MCP-1 (monocyte chemoattractant protein-1) from Exam 7 of the Framingham Offspring Cohort (1998-2001), we constructed a population-normalized, equally weighted log-transformed mean Results: We found a significant association between ICS5 score and increased risk for incident all-cause stroke (hazard ratio, 1.48 [95% CI, 1.05-2.08]; Conclusions: Circulating serum levels of inflammatory biomarkers centered on IL-18 are associated with an increased risk of stroke and cognitive impairment in the Framingham Offspring Cohort. Linking specific inflammatory pathways to cerebral small vessel disease may enhance individualized quantitative risk assessment for future stroke and vascular cognitive impairment.
Language	English
Publishing date	2024-05-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	80381-9
ISSN	1524-4628 ; 0039-2499 ; 0749-7954
ISSN (online)	1524-4628
ISSN	0039-2499 ; 0749-7954
DOI	10.1161/STROKEAHA.123.044719
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Article: Female pattern alopecia: current perspectives.

Levy, Lauren L / Emer, Jason J

International journal of women's health

2013 Volume 5, Page(s) 541–556

Abstract: Hair loss is a commonly encountered problem in clinical practice, with men presenting with a distinctive pattern involving hairline recession and vertex balding (Norwood-Hamilton classification) and women exhibiting diffuse hair thinning over the crown ( ... ...

Abstract	Hair loss is a commonly encountered problem in clinical practice, with men presenting with a distinctive pattern involving hairline recession and vertex balding (Norwood-Hamilton classification) and women exhibiting diffuse hair thinning over the crown (increased part width) and sparing of the frontal hairline (Ludwig classification). Female pattern hair loss has a strikingly overwhelming psychological effect; thus, successful treatments are necessary. Difficulty lies in successful treatment interventions, as only two medications - minoxidil and finasteride - are approved for the treatment of androgenetic alopecia, and these medications offer mediocre results, lack of a permanent cure, and potential complications. Hair transplantation is the only current successful permanent option, and it requires surgical procedures. Several other medical options, such as antiandrogens (eg, spironolactone, oral contraceptives, cyproterone, flutamide, dutasteride), prostaglandin analogs (eg, bimatoprost, latanoprost), and ketoconazole are reported to be beneficial. Laser and light therapies have also become popular despite the lack of a profound benefit. Management of expectations is crucial, and the aim of therapy, given the current therapeutic options, is to slow or stop disease progression with contentment despite patient expectations of permanent hair regrowth. This article reviews current perspectives on therapeutic options for female pattern hair loss.
Language	English
Publishing date	2013-08-29
Publishing country	New Zealand
Document type	Journal Article ; Review
ZDB-ID	2508161-5
ISSN	1179-1411
ISSN	1179-1411
DOI	10.2147/IJWH.S49337
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Article ; Online: Time and belief in exercise importance predict increased activity during initial COVID-19 restrictions in Ireland.

Forde, Cuisle / Wyse, Jason / Barrett, Emer

Health promotion international

2021 Volume 37, Issue 2

Abstract: The aim of this work was to investigate physical activity levels and the associated barriers and facilitators to physical activity in Irish adults during initial COVID-19 restrictions. Members of the general population completed an online questionnaire. ... ...

Abstract	The aim of this work was to investigate physical activity levels and the associated barriers and facilitators to physical activity in Irish adults during initial COVID-19 restrictions. Members of the general population completed an online questionnaire. Responses from 1274 participants (1274/1568, 81% completion rate) indicated that the majority (46.1%, n = 587) of people were more active than usual during the restrictions, however, 28.6% (n = 365) reported being less active. Fifty-five percent (55.3%, n = 702) of participants were meeting public health physical activity guidelines and more than half (53.3%, n = 679) reported finding new ways to be active. Walking (86%, n = 1101), physical activity in the home (47%, n = 593) and online resources (38%, n = 483) were the most frequently reported types of physical activity people engaged in. Having more time to be physically active [OR 2.326 (SD 1.948-2.794)] and a greater belief in the importance of physical activity [OR 1.192 (SD 1.001-1.444)] were predictive of exercising more than usual. Being unable to access their usual means of exercise [OR 1.612 (SD 1.369-1.902)], advised not to go outside the home [OR 1.402 (SD 1.165-1.698)] and working more than usual [OR 1.201 (SD 1.013-1.443)] were predictive of exercising less than usual. There was a positive trend in physical activity engagement by Irish adults during initial COVID-19 restrictions, likely influenced by increased time, belief that exercise was important and increased use of home-based and online exercise resources. However, almost one in three people reported being less active than usual, highlighting the need for targeted support during restriction periods.
MeSH term(s)	Adult ; COVID-19/prevention & control ; Exercise ; Humans ; Ireland ; Surveys and Questionnaires ; Walking
Language	English
Publishing date	2021-10-04
Publishing country	England
Document type	Journal Article
ZDB-ID	1027448-0
ISSN	1460-2245 ; 0957-4824
ISSN (online)	1460-2245
ISSN	0957-4824
DOI	10.1093/heapro/daab113
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Article ; Online: Emotional benefit of cosmetic camouflage in the treatment of facial skin conditions: personal experience and review.

Levy, Lauren L / Emer, Jason J

Clinical, cosmetic and investigational dermatology

2012 Volume 5, Page(s) 173–182

Abstract: Background: Recent studies highlighting the psychological benefits of medical treatment for dermatological skin conditions have demonstrated a clear role for medical therapy in psychological health. Skin conditions, particularly those that are overtly ... ...

Abstract	Background: Recent studies highlighting the psychological benefits of medical treatment for dermatological skin conditions have demonstrated a clear role for medical therapy in psychological health. Skin conditions, particularly those that are overtly visible, such as those located on the face, neck, and hands, often have a profound effect on the daily functioning of those affected. The literature documents significant emotional benefits using medical therapy in conditions such as acne, psoriasis, vitiligo, and rosacea, but there is little evidence documenting similar results with the use of cosmetic camouflage. Here we present a review highlighting the practical use of cosmetic camouflage makeup in patients with facial skin conditions and review its implications for psychological health. Methods: A search of the Medline and Scopus databases was performed to identify articles documenting the emotional benefit of cosmetic camouflage. Results: Cosmetic camouflage provides a significant emotional benefit for patients with facial skin conditions, and this is substantiated by a literature review and personal experience. More clinical studies are needed to assess and validate the findings reported here. Conclusion: Patients with visible skin conditions have increased rates of depression, anxiety, and decreased self-esteem. It is prudent for us to consider therapies that can offer rapid and dramatic results, such as cosmetic camouflage.
Language	English
Publishing date	2012-11-01
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2494852-4
ISSN	1178-7015 ; 1178-7015
ISSN (online)	1178-7015
ISSN	1178-7015
DOI	10.2147/CCID.S33860
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Complications of minimally invasive cosmetic procedures: prevention and management.

Levy, Lauren L / Emer, Jason J

Journal of cutaneous and aesthetic surgery

2011 Volume 5, Issue 2, Page(s) 121–132

Abstract: Over the past decade, facial rejuvenation procedures to circumvent traditional surgery have become increasingly popular. Office-based, minimally invasive procedures can promote a youthful appearance with minimal downtime and low risk of complications. ... ...

Abstract	Over the past decade, facial rejuvenation procedures to circumvent traditional surgery have become increasingly popular. Office-based, minimally invasive procedures can promote a youthful appearance with minimal downtime and low risk of complications. Injectable botulinum toxin (BoNT), soft-tissue fillers, and chemical peels are among the most popular non-invasive rejuvenation procedures, and each has unique applications for improving facial aesthetics. Despite the simplicity and reliability of office-based procedures, complications can occur even with an astute and experienced injector. The goal of any procedure is to perform it properly and safely; thus, early recognition of complications when they do occur is paramount in dictating prevention of long-term sequelae. The most common complications from BoNT and soft-tissue filler injection are bruising, erythema and pain. With chemical peels, it is not uncommon to have erythema, irritation and burning. Fortunately, these side effects are normally transient and have simple remedies. More serious complications include muscle paralysis from BoNT, granuloma formation from soft-tissue filler placement and scarring from chemical peels. Thankfully, these complications are rare and can be avoided with excellent procedure technique, knowledge of facial anatomy, proper patient selection, and appropriate pre- and post-skin care. This article reviews complications of office-based, minimally invasive procedures, with emphasis on prevention and management. Practitioners providing these treatments should be well versed in this subject matter in order to deliver the highest quality care.
Language	English
Publishing date	2011-11-03
Publishing country	India
Document type	Journal Article
ZDB-ID	2461107-4
ISSN	0974-5157 ; 0974-2077
ISSN (online)	0974-5157
ISSN	0974-2077
DOI	10.4103/0974-2077.99451
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